Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors.
نویسندگان
چکیده
A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17alpha-hydroxylase-C(17,20)-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
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عنوان ژورنال:
- Steroids
دوره 72 14 شماره
صفحات -
تاریخ انتشار 2007